Clinical Nuclear Medicine Fourth Edition by Cook, Gary J.R PDF

By Cook, Gary J.R

ISBN-10: 0340812397

ISBN-13: 9780340812396

ISBN-10: 1444113577

ISBN-13: 9781444113570

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Extra resources for Clinical Nuclear Medicine Fourth Edition

Example text

Molecular imaging is perfectly suited to this requirement, and is increasingly being used to optimize treatment regimes in oncology patients. Molecular characterization of tumors Molecular imaging takes advantage of the phenotypic changes that occur in cancer cells to identify protein/receptor expression and metabolic changes that are specific for tumors or are over-expressed compared to normal tissue. The expression of specific receptors can be identified through imaging with SPECT and PET, allowing determination of appropriate treatment to be implemented.

The specific applications of molecular imaging in neurology can be conceptualized in the following categories: • • • • • • • • • • Neurobiology and neuropathology Psychiatry Neuropharmacology Drug abuse and dependency Epilepsy Neurodegenerative conditions Dementing illnesses Movement disorders Brain ischemia Traumatic brain injury Several characteristics of an imaging ligand are of particular interest when selecting agents for use in neurology, including potency, toxicity, plasma protein binding, penetration of the blood–brain barrier and the specific activity (and hence administered mass).

Molecular imaging is perfectly suited to this requirement, and is increasingly being used to optimize treatment regimes in oncology patients. Molecular characterization of tumors Molecular imaging takes advantage of the phenotypic changes that occur in cancer cells to identify protein/receptor expression and metabolic changes that are specific for tumors or are over-expressed compared to normal tissue. The expression of specific receptors can be identified through imaging with SPECT and PET, allowing determination of appropriate treatment to be implemented.

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Clinical Nuclear Medicine Fourth Edition by Cook, Gary J.R


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