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By Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.)

ISBN-10: 0723436584

ISBN-13: 9780723436584

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Sample text

Polymorphism in DNA sequence between individuals can take many forms including differences at a single base pair involving substitution, insertion, or deletion of a single nucleotide (commonly termed ‘single nucleotide polymorphisms’ or SNPs) and repetition, insertion, or deletion of longer stretches of DNA ranging from a few base pairs to many thousands of base pairs, often termed ‘copy number variations’ or CNVs. The different versions of the nucleotide sequence present at any one location in the genome (locus) are termed ‘alleles’.

31 Early and late phase responses in asthma. The asthmatic response to allergen inhalation challenge with house dust mite allergen (green line) and diluent control (red line), demonstrating both an early and a late phase allergic response. FEV1, forced expiratory volume in 1 second. EPR and LPR in the nose In the nose, topical allergen challenge of sensitized individuals causes immediate nasal reactions involving itching, sneezing, congestion, and watery discharges. The early response usually abates within 1–3 hours.

Apart from the consideration of whether either of the studies represents a false negative or positive association, it is important to determine whether the studies truly replicate one another. For example, were they carried out in populations of similar genetic ancestry, or with similar environmental exposures? Were exactly the same polymorphisms studies in the gene and was the phenotype tested the same?  Source: Holloway JW, Yang IA, Holgate ST. Genetics of allergic disease. J Allergy Clin Immunol 2010; 125(2 suppl 2):S81–94.

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Allergy by Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.)


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